Molecular Detection Of Exercise-induced Free Radicals Following Ascorbate Prophylaxis In Type 1 Diabetes Mellitus: A Randomised Controlled Trial
Notes for this study:
||(W). Diabetics: Control: 222±24. Vitamin C: 222±24. Non-diabetics: Control: 246±42. Vitamin C: 258±54
|Number of Subjects
In a randomized, double-blind, placebo-controlled trial, 12 male type-1 diabetic and 14 healthy male participants took a single dose of 1 g vitamin C or placebo prior to an exercise test on a cycle ergometer. The test was to voluntary exhaustion, incremental, and progressive. Blood samples were taken before and after exercise.
There were no statistically significant differences between vitamin C and placebo in either type-1 diabetic or healthy participants for, V0₂ peak, respiratory exchange ratio, heart rate, rate of perceived exertion, power output, exercise time, or glucose levels. Vitamin C supplementation led to a significant reduction in free radicals and lipid hydroperoxides induced by exercise.