Influence Of Vitamin C Supplementation On Oxidative And Immune Changes After An Ultramarathon
Notes for this study:
||Cell count, 10⁹/l. Control: pre 0.36 ± 0.04 mid, 0.21 ± 0.02, end 0.27 ± 0.04. Vitamin C: pre 0.35 ± 0.07, mid 0.23 ± 0.04, end 0.31 ± 0.05
|Number of Subjects
||18-29, 30-44, 45-64, 65+
In a randomized, double-blind, placebo-controlled trial, ultramarathon runners took 500 mg of vitamin C three times per day (1.5 g/d) or placebo for 7 days prior to a race and 500 mg before the race began. 28 participants complied with all protocols and were analyzed.
Funding issues for this study:
As expected, vitamin C in plasma was higher in the vitamin C group. There was a statistically significant difference in uric acid levels between groups, with the placebo group seeing an increase and the vitamin C group seeing no change. There were no statistically significant differences between groups for lipid hydroperoxide, F2-isoprostane, serum glucose, insulin (although there was a notable reduction in the placebo group and increase in the vitamin C group), cortisol, or measures of immune cells or cytokines.
"This work was funded by the Gatorade Sports Science Institute and National Institutes of Health Grants."