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Studies related to Interleukin 2 and Vitamin C

Influence Of Vitamin C Supplementation On Oxidative And Immune Changes After An Ultramarathon

Effect None
Values IL-2, PHA 25 (μg/ml). Control: pre 79.5 ± 22.2 ,mid 49.0 ± 7.1, end 36.6 ± 5.0. Vitamin C: pre 140.3 ± 31.8, mid 95.9 ± 18.7, end 46.1 ± 12.8
Trial Design Randomized trial
Trial Length 1-7 Days
Number of Subjects 28
Sex Both Genders
Age Range 18-29, 30-44, 45-64, 65+
Body Types Trained, Average
Notes for this study:
In a randomized, double-blind, placebo-controlled trial, ultramarathon runners took 500 mg of vitamin C three times per day (1.5 g/d) or placebo for 7 days prior to a race and 500 mg before the race began. 28 participants complied with all protocols and were analyzed.

As expected, vitamin C in plasma was higher in the vitamin C group. There was a statistically significant difference in uric acid levels between groups, with the placebo group seeing an increase and the vitamin C group seeing no change. There were no statistically significant differences between groups for lipid hydroperoxide, F2-isoprostane, serum glucose, insulin (although there was a notable reduction in the placebo group and increase in the vitamin C group), cortisol, or measures of immune cells or cytokines.
Funding issues for this study:
"This work was funded by the Gatorade Sports Science Institute and National Institutes of Health Grants."