Efficacy Of Antioxidant Treatment In Reducing Resistin Serum Levels: A Randomized Study
| Effect | Decrease |
| Values | (ng/ml) Control group: before 4.2 ± 1.0, after 4.3 ± 0.9. Vitamin C: before 4.3 ± 1.5, after 2.9 ± 0.8 |
| Trial Design | Randomized trial |
| Trial Length | 1-2 Weeks |
| Number of Subjects | 80 |
| Sex | Both Genders |
| Age Range | 18-29, 30-44, 45-64 |
| Body Types | Overweight, Average |
In a randomized, open label, controlled (but not placebo-controlled) trial, eighty healthy participants received either 2 g of ascorbic acid or no supplementation for two weeks. The primary outcome was serum resistin. At the end of two weeks, the vitamin C group saw a large, statistically significant reduction in resistin and nitrotyrosine compared with the control group. The vitamin C group also saw an increase in oxidized glutathione and plasma vitamin C. No statistically significant changes were observed for fasting glucose, total cholesterol, HDL cholesterol, triglycerides, fasting insulin, or CRP. Two participants in the vitamin C group complained of gastric discomfort while none did in the control group.
