| Effect | None |
| Values | Fasting (μIU/mL). Placebo: pre 9.4 ± 1.5, post 9.4 ± 1.8. Vitamin C: pre 9.4 ± 1.5, post 9.2 ± 1.6 |
| Trial Design | Randomized trial |
| Trial Length | 1-6 months |
| Number of Subjects | 31 |
| Sex | Both Genders |
| Age Range | 30-44, 45-64, 65+ |
| Body Types | Obese, Overweight |
In a randomized, double-blind, placebo-controlled crossover trial, 31 participants were enrolled 27 completed supplementation of 500 mg of vitamin C (twice daily, total 1000 mg per day) or a placebo for 4 months for each condition. Prior to and after each supplementation period, the participants were evaluated for blood pressure and a variety of blood glucose measures over a 48 hour period using a leave-in glucose sensor that relayed blood values to a computer. The primary outcome was 10.5 hour postprandial glucose (taken from 3.5 hour postprandial periods after each meal). Participants were also evaluated on the second day for fasting glucose, Hba1c, lipids, insulin, placebo ascorbic acid, plasma F2‐isoprostanes, and and renal/liver function.
Participants taking vitamin C saw a modest reduction in blood pressure and 10.5-hour post-prandial glucose and hours per day with post-prandial hyperglycemia, however, there were no significant differences for fasting glucose, insulin, HbA1c, lipids, or measures of liver/kidney function.
