Influence Of Vitamin C Supplementation On Oxidative And Immune Changes After An Ultramarathon
| Effect | None |
| Values | (pg/ml). Control: pre 8.7 ± 2.3, mid 18.0 ± 1.8, end 28.1 ± 3.9. Vitamin C: pre 7.9 ± 1.3, mid 16.4 ± 1.6, end 28.5 ± 3.5 |
| Trial Design | Randomized trial |
| Trial Length | 1-7 Days |
| Number of Subjects | 28 |
| Sex | Both Genders |
| Age Range | 18-29, 30-44, 45-64, 65+ |
| Body Types | Trained, Average |
In a randomized, double-blind, placebo-controlled trial, ultramarathon runners took 500 mg of vitamin C three times per day (1.5 g/d) or placebo for 7 days prior to a race and 500 mg before the race began. 28 participants complied with all protocols and were analyzed.Funding issues for this study:
As expected, vitamin C in plasma was higher in the vitamin C group. There was a statistically significant difference in uric acid levels between groups, with the placebo group seeing an increase and the vitamin C group seeing no change. There were no statistically significant differences between groups for lipid hydroperoxide, F2-isoprostane, serum glucose, insulin (although there was a notable reduction in the placebo group and increase in the vitamin C group), cortisol, or measures of immune cells or cytokines.
"This work was funded by the Gatorade Sports Science Institute and National Institutes of Health Grants."
