Influence Of Vitamin C Supplementation On Oxidative And Immune Changes After An Ultramarathon
| Effect | None |
| Values | Cell count, 10⁹/l. Control: pre 1.41 ± 0.10, mid 1.05 ± 0.11, end 1.04 ± 0.08. Vitamin C: pre 1.44 ± 0.10, mid 1.02 ± 0.06, end 1.03 ± 0.11 |
| Trial Design | Randomized trial |
| Trial Length | 1-7 Days |
| Number of Subjects | 28 |
| Sex | Both Genders |
| Age Range | 18-29, 30-44, 45-64, 65+ |
| Body Types | Trained, Average |
In a randomized, double-blind, placebo-controlled trial, ultramarathon runners took 500 mg of vitamin C three times per day (1.5 g/d) or placebo for 7 days prior to a race and 500 mg before the race began. 28 participants complied with all protocols and were analyzed.Funding issues for this study:
As expected, vitamin C in plasma was higher in the vitamin C group. There was a statistically significant difference in uric acid levels between groups, with the placebo group seeing an increase and the vitamin C group seeing no change. There were no statistically significant differences between groups for lipid hydroperoxide, F2-isoprostane, serum glucose, insulin (although there was a notable reduction in the placebo group and increase in the vitamin C group), cortisol, or measures of immune cells or cytokines.
"This work was funded by the Gatorade Sports Science Institute and National Institutes of Health Grants."
