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| Effect | Increase |
| Values | Peripheral insulin sensitivity index (mg.kg FFM⁻¹.min⁻¹ per µU.ml⁻¹ per mmol.l⁻¹) x 10⁻³. Control: before 9.2 ± 0.7, after 9.0 ± 0.6. Vitamin C: before 9.0 ± 1.1, after 10.9 ± 1.2 |
| Trial Design | Randomized trial |
| Trial Length | 1-6 months |
| Number of Subjects | 13 |
| Sex | Both Genders |
| Age Range | 30-44, 45-64, 65+ |
In a randomized, double-blind, placebo-controlled cross-over study, 13 participants (7 finished) with type 2 diabetes took 500 mg of vitamin C or placebo twice daily for four months per stage, with a one month washout period in between. There were no statistically significant differences between vitamin C and placebo for fasting glucose, fasting insulin, HbA1c, total cholesterol, LDL, HDL, triglycerides, measures of body composition, antioxidant/oxidative stress measures, or various metabolic measures. The only statistically significant differences were for the peripheral insulin sensitivity index, which worsened during placebo and was largely unchanged during vitamin C, and superoxide dismutase activity in skeletal muscle which decreased during vitamin C and increased during placebo.
