Ascorbic Acid Supplementation Improves Skeletal Muscle Oxidative Stress And Insulin Sensitivity In People With Type 2 Diabetes: Findings Of A Randomized Controlled Study
Notes for this study:
||Skeletal muscle (µg.g⁻¹ tissue). Control: before 7.8 ± 1.1, after 8.1 ± 0.6. Vitamin C 8.3 ± 1.1, after 7.9 ± 1.3. Plasma (µmol.l⁻¹). Control: before 268.6 ± 24.2, after 264.3 ± 23.9. Vitamin C: before 264.7 ± 16.l, after 254.4 ± 24.5
|Number of Subjects
||30-44, 45-64, 65+
In a randomized, double-blind, placebo-controlled cross-over study, 13 participants (7 finished) with type 2 diabetes took 500 mg of vitamin C or placebo twice daily for four months per stage, with a one month washout period in between. There were no statistically significant differences between vitamin C and placebo for fasting glucose, fasting insulin, HbA1c, total cholesterol, LDL, HDL, triglycerides, measures of body composition, antioxidant/oxidative stress measures, or various metabolic measures. The only statistically significant differences were for the peripheral insulin sensitivity index, which worsened during placebo and was largely unchanged during vitamin C, and superoxide dismutase activity in skeletal muscle which decreased during vitamin C and increased during placebo.