Studies related to Kidney Function and Vitamin C

Ascorbic Acid Supplementation Improves Postprandial Glycaemic Control And Blood Pressure In Individuals With Type 2 Diabetes: Findings Of A Randomized Cross-over Trial

Effect None
Values eGFR (mL/min/1.73 m−2). Placebo: pre 75.9 ± 1.2, post 73.9 ± 1.2. Vitamin C: pre 76.3 ± 1.2, post 75.3 ± 1.2.
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 31
Sex Both Genders
Age Range 30-44, 45-64, 65+
Body Types Obese, Overweight
Notes for this study:
In a randomized, double-blind, placebo-controlled crossover trial, 31 participants were enrolled 27 completed supplementation of 500 mg of vitamin C (twice daily, total 1000 mg per day) or a placebo for 4 months for each condition. Prior to and after each supplementation period, the participants were evaluated for blood pressure and a variety of blood glucose measures over a 48 hour period using a leave-in glucose sensor that relayed blood values to a computer. The primary outcome was 10.5 hour postprandial glucose (taken from 3.5 hour postprandial periods after each meal). Participants were also evaluated on the second day for fasting glucose, Hba1c, lipids, insulin, placebo ascorbic acid, plasma F2‐isoprostanes, and and renal/liver function.

Participants taking vitamin C saw a modest reduction in blood pressure and 10.5-hour post-prandial glucose and hours per day with post-prandial hyperglycemia, however, there were no significant differences for fasting glucose, insulin, HbA1c, lipids, or measures of liver/kidney function.