Studies related to DHEA and Ashwagandha

A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining The Hormonal And Vitality Effects Of Ashwagandha ( Withania Somnifera) In Aging, Overweight Males

Effect Increase
Values (nmol/L) DHEA-S. Placebo: 8.27 (0.74). Ashwaganda: 9.76 (0.77)
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 57
Sex Male
Age Range 30-44, 45-64, 65+
Body Types Obese, Overweight
Notes for this study:
In a randomized, double-blind, placebo-controlled crossover trial, 57 overweight/obese men reporting fatigue or reduced vitality were assigned to take an ashwagandha extract containing 10.5 mg of withanolide glycosides or placebo for 8 weeks for each crossover condition with no washout period.

The primary outcome was the total score as assessed by the Ageing Males' Symptoms score, and there wasn't a notable difference between groups. Notable differences in fatigue and vigor. A modest statistically significant increase in testosterone and DHEA-S were found while taking ashwaganda, as compared with placebo, and no notable changes in cortisol or estradiol.

No notable adverse events were found.

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