Studies related to Luteinizing Hormone and Ashwagandha

Withania Somnifera Improves Semen Quality By Regulating Reproductive Hormone Levels And Oxidative Stress In Seminal Plasma Of Infertile Males

Effect Increase
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 75
Gender Male
Notes for this study:
After 5 g of withania somnifera root powder daily, sperm quality increased in all three tested groups (three types of male infertility, fertile men were not tested); sperm concentration, overall volume, motility, and count all increased. All tested groups experienced an increase in anti-oxidant enzymes in the semen and a decrease in oxidative products, with the Normozoospermic group having greater levels of catalase than control.

Testosterone and Luteinizing hormone were increased (trend to normalization to control group) and follicle stimulating hormone decreased (trend to normalization with control) in tested groups; fertile men were not tested.

Withania Somnifera Improves Semen Quality In Stress-Related Male Fertility

Effect Increase
Trial Design Cohort
Trial Length 1-6 months
Number of Subjects 60
Gender Male
Age Range 18-29, 30-44
Body Types Average
Notes for this study:
Supplementation of 5 g of the root powder daily with skin milk for 3 months in infertile men with otherwise normal sperm morphology was able to increase sperm concentration and motility with more efficacy in men who were highly stressed (rather than heavy smokers or those who were neither) and was able to increase testosterone (10–22%) and reduce cortisol (11–32% AUC; 36-48% when measured at 4 p.m.) with similar favoring of stressed men.

Clinical Evaluation Of The Spermatogenic Activity Of The Root Extract Of Ashwagandha (Withania Somnifera) In Oligospermic Males: A Pilot Study

Effect Increase
Values Within group. Serum (mIU/ML). Mean + standard deviation. Placebo: before 4.02 ± 1.20, after 4.35 ± 1.28. Ashwagandha before 3.97 ± 1.21, after 5.31 ± 1.33
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 46
Gender Male
Age Range 18-29, 30-44
Notes for this study:
In a randomized, double-blind, placebo-controlled pilot trial, 46 infertile men were assigned to take placebo or 675 mg of a high-concentration, full-spectrum ashwagandha root extract daily for 12 weeks.

The primary outcome was the change in semen parameters and serum hormone levels. The ashwagandha group saw notable and statistically significant increase in sperm concentration, volume, and motility compared with baseline, while the placebo group saw smaller increases which weren't statistically significant compared with baseline. Serum testosterone and luteinizing hormone increased more in the ashwagandha group than the placebo group, but the difference compared with baseline wasn't statistically significant.