Studies related to Processing Accuracy and Ashwagandha

Randomized Placebo-controlled Adjunctive Study Of An Extract Of Withania Somnifera For Cognitive Dysfunction In Bipolar Disorder

Effect None
Values Strategic target detection perseverative errors. Placebo: -5.02 (2.41). Intervention -5.76 (2.66)
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 60
Gender Both Genders
Age Range 18-29, 30-44, 45-64, 65+
Notes for this study:
In a randomized, double-blind, placebo-controlled trial, 60 subjects with bipolar disorder took an ashwagandha extract or placebo for 8 weeks. The subjects who took ashwagandha received 250 mg/d (standardized to a minimum of 8% withanolides and a maximum of 2% Withaferin A) for the first week, and 500 mg for the rest of the study, however, if the participants suspected adverse effects of ashwagandha, they were allowed to reduce their dose to 250 mg/d, which was the case with 3.

The primary outcome was working memory as evaluated by an auditory 8 Digit-Span test. Compared with placebo, the ashwagandha group saw a small, statistically significant improvement in the span backward portion, but not for span forward.

The participants also performed the flanker test and the results favored the ashwagandha group but were only statistically significant for the neutral condition. Results for tests of executive function and processing speed were ambiguous and not statistically significant. The researchers also evaluated affective symptoms and possibly found reductions in depression and mania, but not anxiety, though statistical tests weren't performed for these. The only adverse event that seemed to be higher in the ashwagandha group was diarrhea in 5 participants compared with 1 in the placebo group.

Effect Of Standardized Aqueous Extract Of Withania Somnifera On Tests Of Cognitive And Psychomotor Performance In Healthy Human Participants

Effect None
Trial Design Randomized trial
Trial Length 1-2 Weeks
Number of Subjects 20
Gender Male
Age Range 18-29, 30-44
Notes for this study:
In a randomized, double-blind, placebo-controlled crossover trial, 20 healthy, male participants were assigned to take placebo, 1,000 mg of an aqueous extract of ashwagandha roots and leaves daily for 14 days, before crossing over after a washout period of 14 days, The extract was standardized to contain not less than 10% withanolide glycosides, not more than 0.5% withaferin-A, and not less than 32% oligosaccharides.

The change in reaction time in cognitive and psychomotor tests, together, were the primary outcome. Compared with the placebo group, there were statistically significant improvements in reaction time for the simple reaction test, choice discrimination test, digit symbol substitution test, digit vigilance task, and card sorting test. This, however, didn't translate to improved accuracy.

There were no observed differences in adverse events.