A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining The Hormonal And Vitality Effects Of Ashwagandha ( Withania Somnifera) In Aging, Overweight Males
Notes for this study:
||(pmol/L) Estradiol. Placebo: 23.95 (2.68). Ashwagandha: 21.18 (1.94)
|Number of Subjects
||30-44, 45-64, 65+
In a randomized, double-blind, placebo-controlled crossover trial, 57 overweight/obese men reporting fatigue or reduced vitality were assigned to take an ashwagandha extract containing 10.5 mg of withanolide glycosides or placebo for 8 weeks for each crossover condition with no washout period.
The primary outcome was the total score as assessed by the Ageing Males' Symptoms score, and there wasn't a notable difference between groups. Notable differences in fatigue and vigor. A modest statistically significant increase in testosterone and DHEA-S were found while taking ashwaganda, as compared with placebo, and no notable changes in cortisol or estradiol.
No notable adverse events were found.