Studies related to Liver Enzymes and Ashwagandha

Exploratory Study To Evaluate Tolerability, Safety, And Activity Of Ashwagandha (Withania Somnifera) In Healthy Volunteers

Effect None
Trial Design Cohort
Trial Length 1-6 months
Number of Subjects 17
Gender Both Genders
Age Range 18-29
Body Types Average
Notes for this study:
In an exploratory toxicological study in otherwise healthy persons, supplementation of a water extract at 750 mg for 10 days followed by 1,000 mg and 1,250 mg for 10 days each (equivalent to 6 g, 8g , and 10 g of the dry root) noted a 9.3% reduction in total cholesterol which was thought to be due to LDL cholesterol (trending to decrease) and a significant increase in strength in the quadricep and back extensor muscles (but not grip) was noted after 30 days despite no exercise.

Effects Of An Aqueous Extract Of Withania Somnifera On Strength Training Adaptations And Recovery: The STAR Trial

Effect None
Values ALT. (U/L) Placebo: before 24.8 ± 7.8, after 25.9 ± 8.1. Ashwagandha: before 20.6 ± 9.1, after 22.8 ± 8.2 . AST. Placebo: before 24.8 ± 7.8, after 25.9 ± 8.1. Ashwagandha: before 24.3 ± 9.2, after 22.8 ± 8.2. Alkaline Phosphatase . Placebo: before 73.9 ± 21.4, after 74.3 ± 19.9. Ashwagandha: before 66.4 ± 14.4, after 64.2 ± 11.5
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 40
Gender Male
Age Range 18-29, 30-44, 45-64
Body Types Obese, Overweight, Average
Notes for this study:
In a randomized, double-blind, placebo-controlled trial, 40 healthy young, recreationally active men were allocated to take 500 mg of a potent ashwagandha extract (standardized to 10% withanolides) or placebo for 12 weeks.

The primary outcome was the change in muscle strength as measured by one-repetition maximum with the Smith machine bench press and back squat. There was a statistically significant increase in 1-repetition max for both squat and bench press. While the ashwagandha group saw a greater improvement in 7.5 km running down, this wasn't statistically significant between groups and the same was the case for average and peak power for squats and bench press, and number of repetitions.

There were no statistically significant changes between groups for body fat percentage, lean mass, fat mass, Android/Gynoid Ratio, visceral fat, or body mass. There were no statistically significant differences between groups on subjective assessments on a visual analog scale for perceived recovery, invigoration, mood, desire to work out, willingness to train, optimism, or soreness.

For blood testing, a large number of things were measured but none of it is particularly noteworthy (available in the values box in each respective outcome).
Funding issues for this study:
"Funding for this study was provided by Natreon, Inc. (New Brunswick, NJ, USA) through a restricted grant. The sponsor of the study was not involved in the conduct, interpretation, or the preparation of the final manuscript. A blinded third-party audited the collected data for accuracy and performed the statistical analyses."