| Effect | Decrease |
| Values | -3.47% vs. -1.52% ashwagandha vs. placebo, respectively, while undergoing strength training |
| Trial Design | Randomized trial |
| Trial Length | 1-6 months |
| Number of Subjects | 57 |
| Gender | Male |
| Age Range | 18-29, 30-44, 45-64 |
| Body Types | Untrained |
Untrained men were put on a periodized strength training program and given either placebo or 300 mg of ashwagandha root extract twice daily for 8 weeks. The ashwagandha group improved their 1RM of bench press by almost 20 kg over placebo and leg extension by almost 5 kg. Muscle size, serum testosterone, and muscle recovery as measured by plasma creatine kinase was also improved versus placebo.
| Effect | None |
| Trial Design | Cohort |
| Trial Length | 1-6 months |
| Number of Subjects | 17 |
| Gender | Both Genders |
| Age Range | 18-29 |
| Body Types | Average |
In an exploratory toxicological study in otherwise healthy persons, supplementation of a water extract at 750 mg for 10 days followed by 1,000 mg and 1,250 mg for 10 days each (equivalent to 6 g, 8g , and 10 g of the dry root) noted a 9.3% reduction in total cholesterol which was thought to be due to LDL cholesterol (trending to decrease) and a significant increase in strength in the quadricep and back extensor muscles (but not grip) was noted after 30 days despite no exercise.
