Studies related to Sperm Count and Ashwagandha

Withania Somnifera Improves Semen Quality In Stress-Related Male Fertility

Effect Increase
Trial Design Cohort
Trial Length 1-6 months
Number of Subjects 60
Gender Male
Age Range 18-29, 30-44
Body Types Average
Notes for this study:
Supplementation of 5 g of the root powder daily with skin milk for 3 months in infertile men with otherwise normal sperm morphology was able to increase sperm concentration and motility with more efficacy in men who were highly stressed (rather than heavy smokers or those who were neither) and was able to increase testosterone (10–22%) and reduce cortisol (11–32% AUC; 36-48% when measured at 4 p.m.) with similar favoring of stressed men.

Comparative Evaluation Of The Effects Of Withania Somnifera With Pentoxifylline On The Sperm Parameters In Idiopathic Male Infertility: A Triple-blind Randomised Clinical Trial

Effect Increase
Values (within group) (×10⁶ ). Before 55.82 (28.45), after 62.65 (33.66).
Trial Design Randomized trial
Trial Length 2-4 Weeks
Number of Subjects 100
Gender Male
Age Range 18-29, 30-44, 45-64
Body Types Obese, Overweight, Average
Notes for this study:
In a randomized, triple-blind trial, 100 infertile men were assigned to take 5 g of ashwagandha root, or pentoxifylline daily for 90 days.

The primary outcome was the improvement of sperm parameters (count, motility, morphology, semen volume). Semen volume was unchanged in the ashwagandha group and the pentoxifylline group saw a statistically significant improvement. The ashwagandha group saw a statistically significant improvement in sperm count, whereas the pentoxifylline group saw no change. Progressive motility improved significantly and comparably in both groups. Total motility sperm count was significantly improved in the ashwagandha group but not the pentoxifylline group. Percentage of sperm with normal morphology was significantly improved in the ashagandha group but not the pentoxifylline group, and round cells were not statistically significantly lower in the ashwagandha group, but the pentoxifylline group saw a significant reduction. There were no statistically significant between-group differences, however.

Notable events weren't found for ashwagandha.

Clinical Evaluation Of The Spermatogenic Activity Of The Root Extract Of Ashwagandha (Withania Somnifera) In Oligospermic Males: A Pilot Study

Effect Increase
Values Within group. Sperm concentration (×10⁶/mL). Mean + standard deviation. Placebo: before 10.24 ± 2.82, after 13.23 ± 7.74. Ashwagandha: before 9.59 ± 4.37, after 25.61 ± 8.6.
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 46
Gender Male
Age Range 18-29, 30-44
Notes for this study:
In a randomized, double-blind, placebo-controlled pilot trial, 46 infertile men were assigned to take placebo or 675 mg of a high-concentration, full-spectrum ashwagandha root extract daily for 12 weeks.

The primary outcome was the change in semen parameters and serum hormone levels. The ashwagandha group saw notable and statistically significant increase in sperm concentration, volume, and motility compared with baseline, while the placebo group saw smaller increases which weren't statistically significant compared with baseline. Serum testosterone and luteinizing hormone increased more in the ashwagandha group than the placebo group, but the difference compared with baseline wasn't statistically significant.