Studies related to Sleep Quality and Ashwagandha

Adaptogenic And Anxiolytic Effects Of Ashwagandha Root Extract In Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study

Effect Increase
Values 7-point scale. 1=best, 7=worst. Mean and SD. Placebo: before 5.85 (0.87), after 4.89 (0.87). Low dose: before 5.85 (0.74), after 3.79 (1.13). High dose: before 5.65 (0.81), after 3.05 (1.39).
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 60
Sex Both Genders
Age Range 18-29, 45-64
Notes for this study:
In a randomized, double-blind, placebo-controlled trial, 60 healthy participants who reported high levels of stress were allocated to take a placebo, 250 mg of an ashwagandha extract or 600 mg of an extract for 8 weeks. The extract was derived from roots and was standardized to 5% withanolides.

There was a statistically significantly greater reduction in score on the Perceived Stress Scale in both ashwagandha groups than for placebo, though the difference was small/modest. The reduction in serum cortisol in the ashwagandha groups was notably greater than for placebo, and the reduction in score on the Hamilton Anxiety Rating Scale (HAM-A) was statistically significantly greater for the high dose group but not the low-dose group. The improvements in sleep quality were greater for both ashwagandha groups than for placebo, and the greatest for the high dose group.

Notable differences between groups for adverse events weren't found.
Funding issues for this study:
Unclear funding. The authors declared that they had no conflicts of interest, and Ixoreal Biomed Inc supplied the supplement for free.

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