Studies related to Pain and Ashwagandha

Effect Of Withania Somnifera (Ashwagandha) On The Development Of Chemotherapy-induced Fatigue And Quality Of Life In Breast Cancer Patients

Effect Decrease
Trial Design Cohort
Trial Length n/a
Number of Subjects 100
Gender Female
Age Range 45-64
Body Types Average
Notes for this study:
Supplementation of 2g of the root of ashwagandha thrice daily over six cycles of chemotherapy was able to significantly improve general function and reduce fatigue relative to control.

A Randomized, Double Blind Placebo Controlled Study Of Efficacy And Tolerability Of Withaina Somnifera Extracts In Knee Joint Pain

Effect Decrease
Values VAS. Placebo: before 60.25 ± 4.11, after 57.4 ± 3.68. 250 mg: before 63.8 ± 2.78, after 53.3 ± 4.02. 500 mg: before 67.25 ± 4.48, after 43.9 ± 3.30
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 60
Gender Both Genders
Age Range 30-44, 45-64, 65+
Notes for this study:
In a randomized, double-blind, placebo-controlled trial, 60 participants with knee joint pain were assigned to take ashwagandha at a dose of 250 mg or 500 mg (standardized to not less than 10% Withanolide glycosides, not less than 32% oligosaccharides and not more than 0.5% of Withaferin- A), or placebo daily for 12 weeks.

The primary outcome was the percentage change in the Modified Western Ontario and McMaster University Osteoarthritis Index (mWOMAC) after 12 weeks. There was a statistically significant reduction in score for both groups compared with placebo, and the high dose group saw a greater, statistically significant reduction compared with the low dose group. Knee swelling only declined in the high dose group compared with the placebo, while the groups had the same relationship for pain, stiffness and physical function as for the overall score. The same was the case for pain on a visual analog scale.

The frequency of using rescue medication was 10 participants in the high dose group, 13 in the low dose group, and 17 in the placebo group. No notable adverse events or worrying blood tests were found.