Studies related to ADHD and Modafinil

Efficacy And Safety Of Modafinil Film-coated Tablets In Children And Adolescents With Attention-deficit/hyperactivity Disorder: Results Of A Randomized, Double-blind, Placebo-controlled, Flexible-dose Study

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 246
Sex Both Genders
Age Range 7-12, 13-17
Body Types Average
Notes for this study:
Supplementation of modafinil at a variable dose of 170-425mg daily over the course of six weeks was associated with significant improvements in attention (with 48% of the sample reporting 'much' or 'very much' when asked how symptoms were improved relative to 17% in placebo) in youth as assessed by the ADHD-RS-IV and CGI-I rating scales. Both inattention and hyperactivity were beneficially influenced, and cognition (impaired by inattention) was significantly improved as well.

Appetite was reported as a side-effect in 16% of participants, which was significantly more than placebo. There was a trend for weight gain in placebo and weight loss in modafinil, but neither reached significance.