| Effect | None |
| Values | Warning: probable errors in paper regarding lack of decimal points. after the third digit. μIU/mL. Mean and SD. Placebo: before 19.4 (26.4), after 19.4 (18.5). Theanine: before 20.5 (22.2), after 21.2 (22.9). |
| Trial Design | Randomized trial |
| Trial Length | 1-6 months |
| Number of Subjects | 60 |
| Sex | Both Genders |
This was a secondary analysis of an 8-week randomized, double-blind, placebo-controlled trial where 60 patients with schizophrenia took 400 mg/d of theanine in addition to ongoing antipsychotic treatment.
There was a greater increase in BDNF and DHEAS in the theanine group, but the difference between groups wasn't statistically significant. There wasn't a difference for insulin, cholesterol, DHEA, and cortisol declined more in the placebo group, but this wasn't statistically significant. Further analysis saw a potential relationship between dysphoric mood, cortisol-to DHEAS ratio, BDNF, and anxiety and DHEAS ratio, and BDNF.
