Studies related to Depression and Theanine

L-theanine In The Adjunctive Treatment Of Generalized Anxiety Disorder: A Double-blind, Randomised, Placebo-controlled Trial

Effect None
Values Montgomery-Asberg Depression Rating Scale. Mean and SD. Placebo: before 11.9 (3.86), after 9.17 (6.86, 11.5). Theanine: before 12.9 (2.85), after 11.3 (9.08, 13.5).
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 46
Sex Both Genders
Age Range 18-29, 30-44, 45-64, 65+
Notes for this study:
In a randomized, double-blind, placebo-controlled trial 46 participants with generalized anxiety disorder were allocated to take 450 mg of theanine (in two divided doses of the course of the day, or placebo for 8 weeks.

The primary outcomes were anxiety and insomnia. There were no statistically significant or notable differences between groups for anxiety outcomes. There was a small advantage of theanine for insomnia, but the difference wasn't statistically significant. Additionally, the change in depression rating wasn't notably different.
Funding issues for this study:
"JS is supported by an NHMRC Clinical Research Fellowship (APP
1125000). The study was co-sponsored by FIT-BioCeuticals. No funding
source was involved in the design, statistical analysis or preparation of
this manuscript. Study sponsors similarly played no role in the decision
to submit this manuscript for publication."

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