Studies related to Serum BDNF and Theanine

Serum Levels Of Brain-derived Neurotrophic Factor And Cortisol To Sulfate Of Dehydroepiandrosterone Molar Ratio Associated With Clinical Response To L-theanine As Augmentation Of Antipsychotic Therapy In Schizophrenia And Schizoaffective Disorder Patients

Effect Increase
Values Warning: probable errors in paper regarding lack of decimal points. after the third digit. pg/mL. Mean and SD. Placebo: before 4951 (4061), after 4711 (4276). Theanine: before 5877 (3881), after 6222 (3887).
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 60
Sex Both Genders
Notes for this study:
This was a secondary analysis of an 8-week randomized, double-blind, placebo-controlled trial where 60 patients with schizophrenia took 400 mg/d of theanine in addition to ongoing antipsychotic treatment.

There was a greater increase in BDNF and DHEAS in the theanine group, but the difference between groups wasn't statistically significant. There wasn't a difference for insulin, cholesterol, DHEA, and cortisol declined more in the placebo group, but this wasn't statistically significant. Further analysis saw a potential relationship between dysphoric mood, cortisol-to DHEAS ratio, BDNF, and anxiety and DHEAS ratio, and BDNF.