Serum Levels Of Brain-derived Neurotrophic Factor And Cortisol To Sulfate Of Dehydroepiandrosterone Molar Ratio Associated With Clinical Response To L-theanine As Augmentation Of Antipsychotic Therapy In Schizophrenia And Schizoaffective Disorder Patients
|Values||nmol/L. Mean and SD. Placebo: before 526.8 (309.7), after 454.3 (120.7). Theanine: before 440.7 (124.7), after 426.7 (114.6).|
|Trial Design||Randomized trial|
|Trial Length||1-6 months|
|Number of Subjects||60|
This was a secondary analysis of an 8-week randomized, double-blind, placebo-controlled trial where 60 patients with schizophrenia took 400 mg/d of theanine in addition to ongoing antipsychotic treatment.
There was a greater increase in BDNF and DHEAS in the theanine group, but the difference between groups wasn't statistically significant. There wasn't a difference for insulin, cholesterol, DHEA, and cortisol declined more in the placebo group, but this wasn't statistically significant. Further analysis saw a potential relationship between dysphoric mood, cortisol-to DHEAS ratio, BDNF, and anxiety and DHEAS ratio, and BDNF.