Treatment Of Metabolic Acidosis In Patients With Stage 3 Chronic Kidney Disease With Fruits And Vegetables Or Oral Bicarbonate Reduces Urine Angiotensinogen And Preserves Glomerular Filtration Rate

Effect Increase
Values Before/after for usual care: -0.6±0.6. Before/after for NaHCO3 supplement: +0.9±0.6. Before/after for fruit & vegetable diet: +0.9±0.6
Trial Design Randomized trial
Trial Length 6+ Months
Number of Subjects 108
Sex Both Genders
Age Range 45-64
Body Types Obese, Overweight, Average
Notes for this study:
This was a 3-year trial that randomized 108 people with stage-3 chronic kidney disease and mild metabolic acidosis (22 mmol/l < plasma TCO2 < 24 mmol/l) to three different groups: added fruit and vegetables, oral NaHCO 30.3 mEq/Kg in three divided doses per day, and usual care.

Compared to baseline, TCO2 decreased in the usual care group, and increased in the fruit and vegetable group and the NaHCO group, representing positive changes in metabolic acidosis. The effect of the fruit and vegetables group was not significantly different from the NaHCO group, and both were significantly different from usual care. The change in renal acid load as measured by 8-hour urine net-acid excretion from baseline decreased only in the fruit and vegetable group.