Isolated Isoflavones Do Not Affect The Circulating Insulin-like Growth Factor System In Men At Increased Colorectal Cancer Risk
Notes for this study:
|Number of Subjects
In men with a history of colon cancer given 80mg Promensil (40mg twice daily) over the course of eight weeks failed to significantly reduce IGF-1 (free or total) and IGF-II while all three binding proteins (IGFBP1-3) were also similarly not affected. In controlling for those who produced equol (23% of sample; those with serum equol higher than 83nM) there was a decrease in total IGF-1 whereas the binding proteins were still unaffected.