Studies related to IGF-1 and Red Clover Extract

Isolated Isoflavones Do Not Affect The Circulating Insulin-like Growth Factor System In Men At Increased Colorectal Cancer Risk

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 37
Gender Male
Age Range 45-64
Body Types Overweight
Notes for this study:
In men with a history of colon cancer given 80mg Promensil (40mg twice daily) over the course of eight weeks failed to significantly reduce IGF-1 (free or total) and IGF-II while all three binding proteins (IGFBP1-3) were also similarly not affected. In controlling for those who produced equol (23% of sample; those with serum equol higher than 83nM) there was a decrease in total IGF-1 whereas the binding proteins were still unaffected.

No Effect Of Red Clover-derived Isoflavone Intervention On The Insulin-like Growth Factor System In Women At Increased Risk Of Colorectal Cancer

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 34
Gender Female
Age Range 45-64
Body Types Overweight
Notes for this study:
Supplementation of 40mg Promensil twice daily in women with a family history of colon cancer failed to significantly alter IGF levels in serum or their binding proteins and did not influence estrogen nor SHBG levels; there was a very large interindividual variation seen in levels of IGFBP-2 (from a 50% reduction to a 500% increase) which was too variable to reach statistical significance.

Effect Of Red Clover-derived Isoflavone Supplementation On Insulin-like Growth Factor, Lipid And Antioxidant Status In Healthy Female Volunteers: A Pilot Study

Effect None
Trial Design Double blind
Trial Length 2-4 Weeks
Number of Subjects 23
Gender Female
Age Range 18-29, 30-44, 45-64
Body Types Overweight, Average
Notes for this study:
Supplementation of 40mg Promensil twice daily over the course of one month was able to slightly increase HDL-C concentrations () while there was no influence on IGF or any of its binding proteins, although when excluding postmenopausal women from the analysis there was a trend to reduce IGF-1 only.