Effects Of A Red Clover Extract (MF11RCE) On Endometrium And Sex Hormones In Postmenopausal Women
| Effect |
None |
| Trial Design |
Double blind |
| Trial Length |
1-6 months |
| Number of Subjects |
109 |
| Gender |
Female |
| Age Range |
45-64 |
| Body Types |
Average |
Notes for this study:
In postmenopausal women given the isoflavone supplement (MF11RCE) at 40mg twice daily for a period of 90 days, supplementation failed to influence estrogen or SHBG but appeared to increase testosterone concentrations in serum (22%) and decreased endometrial thickness.
Red-clover-derived Isoflavones And Mammographic Breast Density: A Double-blind, Randomized, Placebo-controlled Trial ISRCTN42940165
| Effect |
None |
| Trial Design |
Double blind |
| Trial Length |
6+ Months |
| Number of Subjects |
177 |
| Gender |
Both Genders |
| Age Range |
45-64 |
| Body Types |
Overweight, Average |
Notes for this study:
One year of supplementation of 40mg Promensil was unable to exert appreciable estrogenic or antiestrogenic properties in the breast tissue of menopausal women without breast cancer as assessed by mammography; that being said, women with an ESR1 (estrogen receptor) genotype had minor antiestrogenic properties despite no differences in baseline levels.
Funding issues for this study:
Funded by Novagen, producers of Promensil
The Effect Of Red Clover Isoflavones On Menopausal Symptoms, Lipids And Vaginal Cytology In Menopausal Women: A Randomized, Double-blind, Placebo-controlled Study
| Effect |
None |
| Trial Design |
Double blind |
| Trial Length |
1-6 months |
| Number of Subjects |
53 |
| Gender |
Female |
| Age Range |
45-64, 65+ |
| Body Types |
Overweight, Average |
Notes for this study:
Supplementation of 80mg of red clover isoflavones daily to postmenopausal women for 90 days was able to reduce symptoms of menopause with minimal effects on the cardiovascular system nor the hormonal system.
