Studies related to Estrogen and Red Clover Extract

Randomized Placebo-controlled Trial Of An Isoflavone Supplement And Menopausal Symptoms In Women

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 43
Gender Female
Age Range 45-64
Body Types Overweight
Notes for this study:
Supplementation of 40mg Promensil daily over the course of three months was noted to reduce hot flashes relative to placebo when measured at four weeks, but over the course of the 12 week study there were no significant differences in overall menopausal symptoms (Greene Climacteric Scale) or hot flash occurrence.
Funding issues for this study:
Study was Financially Supported by producers of the supplement; Novagen

Effect Of Oral Phytoestrogen On Androgenicity And Insulin Sensitivity In Postmenopausal Women

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 43
Gender Female
Age Range 45-64
Body Types Overweight
Notes for this study:
Supplementation of 40-80mg of Promensil daily for three months in healthy postmenopausal women failed to significantly influence circulating hormones, but appeared to reduce insulin sensitivity as assessed by QUICKI.

Effects Of A Red Clover Extract (MF11RCE) On Endometrium And Sex Hormones In Postmenopausal Women

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 109
Gender Female
Age Range 45-64
Body Types Average
Notes for this study:
In postmenopausal women given the isoflavone supplement (MF11RCE) at 40mg twice daily for a period of 90 days, supplementation failed to influence estrogen or SHBG but appeared to increase testosterone concentrations in serum (22%) and decreased endometrial thickness.

No Effect Of Red Clover-derived Isoflavone Intervention On The Insulin-like Growth Factor System In Women At Increased Risk Of Colorectal Cancer

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 34
Gender Female
Age Range 45-64
Body Types Overweight
Notes for this study:
Supplementation of 40mg Promensil twice daily in women with a family history of colon cancer failed to significantly alter IGF levels in serum or their binding proteins and did not influence estrogen nor SHBG levels; there was a very large interindividual variation seen in levels of IGFBP-2 (from a 50% reduction to a 500% increase) which was too variable to reach statistical significance.

Red-clover-derived Isoflavones And Mammographic Breast Density: A Double-blind, Randomized, Placebo-controlled Trial ISRCTN42940165

Effect None
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 177
Gender Both Genders
Age Range 45-64
Body Types Overweight, Average
Notes for this study:
One year of supplementation of 40mg Promensil was unable to exert appreciable estrogenic or antiestrogenic properties in the breast tissue of menopausal women without breast cancer as assessed by mammography; that being said, women with an ESR1 (estrogen receptor) genotype had minor antiestrogenic properties despite no differences in baseline levels.
Funding issues for this study:
Funded by Novagen, producers of Promensil

The Effect Of Red Clover Isoflavones On Menopausal Symptoms, Lipids And Vaginal Cytology In Menopausal Women: A Randomized, Double-blind, Placebo-controlled Study

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 53
Gender Female
Age Range 45-64, 65+
Body Types Overweight, Average
Notes for this study:
Supplementation of 80mg of red clover isoflavones daily to postmenopausal women for 90 days was able to reduce symptoms of menopause with minimal effects on the cardiovascular system nor the hormonal system.