Studies related to Weight and Red Clover Extract

Randomized Placebo-controlled Trial Of An Isoflavone Supplement And Menopausal Symptoms In Women

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 43
Gender Female
Age Range 45-64
Body Types Overweight
Notes for this study:
Supplementation of 40mg Promensil daily over the course of three months was noted to reduce hot flashes relative to placebo when measured at four weeks, but over the course of the 12 week study there were no significant differences in overall menopausal symptoms (Greene Climacteric Scale) or hot flash occurrence.
Funding issues for this study:
Study was Financially Supported by producers of the supplement; Novagen

Influence Of Red Clover-derived Isoflavones On Serum Lipid Profile In Postmenopausal Women

Effect None
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 96
Gender Female
Age Range 45-64
Body Types Overweight
Notes for this study:
Supplementation of 40mg isoflavones from red clover daily over a period of one year was able to increase HDL cholesterol (19%) and reduced LDL (17.5%) and total cholesterol (12.5%) while the influence on triglycerides (11.5%) failed to reach significance; while the aforementioned numbers refer to the 12 month point, benefits were seen after three months and persisted until 12 months at a similar magnitude.

The Effects Of Dietary Supplementation With Isoflavones From Red Clover On Cognitive Function In Postmenopausal Women

Effect None
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 28
Gender Female
Age Range 65+
Body Types Overweight
Notes for this study:
In postmenopausal women greater than sixty years of age, a formononetin rich isoflavone supplement from red clover (Rimostil) daily for a period of six months failed to alter attention processing (Trail making tests) and had a small improvement in the block design test (visual spatial reasoning) yet failed to influence most parameters while placebo tended to outperform on a digit span test and in a verbal memory test.

The Effects Of Dietary Supplementation With Isoflavones From Red Clover On The Lipoprotein Profiles Of Post Menopausal Women With Mild To Moderate Hypercholesterolaemia

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 75
Gender Female
Age Range 45-64
Body Types Overweight
Notes for this study:
In a preliminary study where postmenopausal women with high cholesterol were given active treatment (40-80mg of red clover isoflavones) or placebo in a 6:1 ratio, supplementation over 12 weeks failed to significantly reduce circulating cholesterol or triglycerides and also failed to alter blood pressure or weight.
Funding issues for this study:
Funded by Novagen, producers of Promensil

Effects Of Dietary Supplementation With Isoflavones From Red Clover On Ambulatory Blood Pressure And Endothelial Function In Postmenopausal Type 2 Diabetes

Effect None
Trial Design Double blind
Trial Length 2-4 Weeks
Number of Subjects 16
Gender Female
Age Range 45-64, 65+
Body Types Obese, Overweight
Notes for this study:
Oral supplementation of 50mg isoflavones (mostly formononetin) from red clover for four weeks in postmenopausal women with type II diabetics was able to improve basal blood flow as assessed by forearm resistance (L-NMMA treatment) and reduced blood pressure by 8mmHg systolic and 4.3mmHg diastolic. No statistically significant changes were noted elsewhere.

The Effects Of Phytoestrogen Isoflavones On Bone Density In Women: A Double-blind, Randomized, Placebo-controlled Trial

Effect None
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 177
Gender Female
Age Range 45-64
Body Types Average
Notes for this study:
Supplementation of 40mg isoflavones from red clover extract daily over the course of a year was able to attenuate the rate of lumbar bone losses () while it had no influence on bone mineral density or bone mineral content of the hip.

The Effect Of Red Clover Isoflavones On Menopausal Symptoms, Lipids And Vaginal Cytology In Menopausal Women: A Randomized, Double-blind, Placebo-controlled Study

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 53
Gender Female
Age Range 45-64, 65+
Body Types Overweight, Average
Notes for this study:
Supplementation of 80mg of red clover isoflavones daily to postmenopausal women for 90 days was able to reduce symptoms of menopause with minimal effects on the cardiovascular system nor the hormonal system.