| Effect | Decrease |
| Trial Design | Cohort |
| Trial Length | 1-6 months |
| Number of Subjects | 17 |
| Gender | Female |
| Age Range | 45-64 |
| Body Types | Overweight, Average |
As assessed by ultrasound, red clover extract (40-80mg isoflavones) appears to increase arterial compliance by up to 23% in otherwise healthy postmenopausal women despite no influence on circulating lipids relative to placebo group (randomization had 5-fold more women in active treatment than placebo, and the sample size was only 17).Funding issues for this study:
(Rating of C given to this study due to the low sample in placebo group and a high dropout rate of 35%)
Supplies provided by Novagen, study not funded by Novagen
Isoflavones Reduce Arterial Stiffness: A Placebo-controlled Study In Men And Postmenopausal Women
| Effect | Decrease |
| Trial Design | Double blind |
| Trial Length | 1-6 months |
| Number of Subjects | 80 |
| Gender | Both Genders |
| Age Range | 45-64, 65+ |
| Body Types | Overweight, Average |
In otherwise healthy older individuals, 80mg of the red clover isoflavones over six weeks weeks was able to reduce arterial stiffness without necessarily affecting blood flow nor pressure, which was thought to be due to the formononetin content (which also decreased VCAM-1).Funding issues for this study:
Funded by Novagen, producers of Promensil