Studies related to Arterial Stiffness and Red Clover Extract

Isoflavones From Red Clover Improve Systemic Arterial Compliance But Not Plasma Lipids In Menopausal Women

Effect Decrease
Trial Design Cohort
Trial Length 1-6 months
Number of Subjects 17
Gender Female
Age Range 45-64
Body Types Overweight, Average
Notes for this study:
As assessed by ultrasound, red clover extract (40-80mg isoflavones) appears to increase arterial compliance by up to 23% in otherwise healthy postmenopausal women despite no influence on circulating lipids relative to placebo group (randomization had 5-fold more women in active treatment than placebo, and the sample size was only 17).

(Rating of C given to this study due to the low sample in placebo group and a high dropout rate of 35%)
Funding issues for this study:
Supplies provided by Novagen, study not funded by Novagen

Isoflavones Reduce Arterial Stiffness: A Placebo-controlled Study In Men And Postmenopausal Women

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 80
Gender Both Genders
Age Range 45-64, 65+
Body Types Overweight, Average
Notes for this study:
In otherwise healthy older individuals, 80mg of the red clover isoflavones over six weeks weeks was able to reduce arterial stiffness without necessarily affecting blood flow nor pressure, which was thought to be due to the formononetin content (which also decreased VCAM-1).
Funding issues for this study:
Funded by Novagen, producers of Promensil