Studies related to Symptoms of Menopause and Red Clover Extract

Randomized Placebo-controlled Trial Of An Isoflavone Supplement And Menopausal Symptoms In Women

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 43
Gender Female
Age Range 45-64
Body Types Overweight
Notes for this study:
Supplementation of 40mg Promensil daily over the course of three months was noted to reduce hot flashes relative to placebo when measured at four weeks, but over the course of the 12 week study there were no significant differences in overall menopausal symptoms (Greene Climacteric Scale) or hot flash occurrence.
Funding issues for this study:
Study was Financially Supported by producers of the supplement; Novagen

Isoflavones From Red Clover (Promensil) Significantly Reduce Menopausal Hot Flush Symptoms Compared With Placebo

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 26
Gender Female
Age Range 45-64
Body Types Overweight, Average
Notes for this study:
One study utilizing a double placebo group for the first four weeks of supplementation before 80mg of Promensil was then given for the next 12 weeks noted that the reduction in hot flashes (44% at the end of the trial, 33% within three weeks) and general menopausal symptoms which were greater than placebo.
Funding issues for this study:
Funded by Novagen, producers of Promensil

The Effect Of Promensil, An Isoflavone Extract, On Menopausal Symptoms

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 37
Gender Female
Age Range 45-64
Body Types Overweight
Notes for this study:
Supplementation of 40mg Promensil, but not 160mg, was able to increase HDL-C in postmenopausal women by 18% after twelve weeks, but no other biochemical marker nor menopausal symptom appeared to be influenced.
Funding issues for this study:
Funded by Novagen, producers of Promensil

Phytoestrogen Supplements For The Treatment Of Hot Flashes: The Isoflavone Clover Extract (ICE) Study: A Randomized Controlled Trial

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 246
Gender Female
Age Range 45-64
Body Types Overweight, Average
Notes for this study:
Supplementation of 80mg Promensil daily, despite having a slight but significant reduction in hot flashes when measured early on in the study, failed to have a significantly protective effect after 12 weeks relative to placebo when looking at the whole group.

It seemed that, when doing subgroup analysis, that Promensil was significantly more effective than placebo in overweight women (BMI greater than 25) while thin women were not significantly different; subgroup analysis for years in menopause, urinary isoflavones, or baseline FSH were not associated with hot flashes.

Phytoestrogen Supplements For The Treatment Of Hot Flashes: The Isoflavone Clover Extract (ICE) Study: A Randomized Controlled Trial

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 246
Gender Female
Age Range 45-64
Body Types Overweight, Average
Notes for this study:
Supplementation of 80mg Promensil daily, despite having a slight but significant reduction in hot flashes when measured early on in the study, failed to have a significantly protective effect after 12 weeks relative to placebo when looking at the whole group.

It seemed that, when doing subgroup analysis, that Promensil was significantly more effective than placebo in overweight women (BMI greater than 25) while thin women were not significantly different; subgroup analysis for years in menopause, urinary isoflavones, or baseline FSH were not associated with hot flashes.

The Effect Of Red Clover Isoflavone Supplementation Over Vasomotor And Menopausal Symptoms In Postmenopausal Women

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 109
Gender Female
Age Range 45-64
Body Types Average
Notes for this study:
Supplementation of 80mg of red clover isoflavones daily for 90 days in postmenopausal women was able to significantly reduce symptoms of menopause as assessed by the Kupperman Index (75.4%), hot flash frequency (73.5%), and night sweats (72.2%) when measured after three months, with these benefits ceasing to exist after three months of supplement cessation.

Red-clover-derived Isoflavones And Mammographic Breast Density: A Double-blind, Randomized, Placebo-controlled Trial ISRCTN42940165

Effect None
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 177
Gender Both Genders
Age Range 45-64
Body Types Overweight, Average
Notes for this study:
One year of supplementation of 40mg Promensil was unable to exert appreciable estrogenic or antiestrogenic properties in the breast tissue of menopausal women without breast cancer as assessed by mammography; that being said, women with an ESR1 (estrogen receptor) genotype had minor antiestrogenic properties despite no differences in baseline levels.
Funding issues for this study:
Funded by Novagen, producers of Promensil

Safety And Efficacy Of Black Cohosh And Red Clover For The Management Of Vasomotor Symptoms: A Randomized Controlled Trial

Effect None
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 80
Gender Female
Age Range 45-64
Body Types Overweight, Average
Notes for this study:
Oral supplementation of 398mg red clover extract (120mg isoflavones) for the course of one year failed to improve any vasomotor (hot flash) symptoms of menopause relative to placebo, in a trial where black cohosh was minorly effective and estrogen replacement therapy highly effective.

There was a minor improvement in anxiety symptoms as assessed by the Greene Anxiety scores after 12 months, but not three.

Effects Of Trifolium Pratense On The Climacteric And Sexual Symptoms In Postmenopause Women

Effect None
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 100
Gender Female
Age Range 45-64
Body Types Obese, Overweight
Notes for this study:
Supplementation of 40mg red clover isoflavones was noted to improve menopausal symptoms (Kupperman Index) after four months, but to a degree comparable with placebo; supplementation failed to reduce symptoms to a level greater than placebo when taken over the course of a year, and sexual function in menopausal women was similarly unaffected.

Effect Of Red Clover Isoflavones Over Skin, Appendages, And Mucosal Status In Postmenopausal Women

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 109
Gender Female
Age Range 45-64
Body Types Average
Notes for this study:
Supplementation of 80mg red clover isoflavones daily over the course of ninety days appeared to be able to increase skin and hair quality, and the improvement in nail quality was present only in half of the study (crossover design) while all improvements had a high variability. Ocular dryness was reduced, and overall symptoms (libido, sleep disturbances, mood) were all improved with treatment relative to placebo.

The Effects Of Red Clover On Quality Of Life In Post-menopausal Women

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 72
Gender Female
Age Range 45-64
Body Types Average
Notes for this study:
In women given red clover isoflavone supplementation, there was an improvement in menopausal symptoms and overall quality of life that failed to outperform placebo.

The Effect Of Red Clover Isoflavones On Menopausal Symptoms, Lipids And Vaginal Cytology In Menopausal Women: A Randomized, Double-blind, Placebo-controlled Study

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 53
Gender Female
Age Range 45-64, 65+
Body Types Overweight, Average
Notes for this study:
Supplementation of 80mg of red clover isoflavones daily to postmenopausal women for 90 days was able to reduce symptoms of menopause with minimal effects on the cardiovascular system nor the hormonal system.