Studies related to Breast Density and Red Clover Extract

Red-clover-derived Isoflavones And Mammographic Breast Density: A Double-blind, Randomized, Placebo-controlled Trial ISRCTN42940165

Effect None
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 177
Gender Both Genders
Age Range 45-64
Body Types Overweight, Average
Notes for this study:
One year of supplementation of 40mg Promensil was unable to exert appreciable estrogenic or antiestrogenic properties in the breast tissue of menopausal women without breast cancer as assessed by mammography; that being said, women with an ESR1 (estrogen receptor) genotype had minor antiestrogenic properties despite no differences in baseline levels.
Funding issues for this study:
Funded by Novagen, producers of Promensil

Red Clover Isoflavones Are Safe And Well Tolerated In Women With A Family History Of Breast Cancer

Effect None
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 401
Gender Female
Age Range 45-64
Body Types Average
Notes for this study:
Supplementation of red clover extract daily over the course of three years was safe and well tolerated in premenopausal and postmenopausal women, but was unable to influence breast density in women with a family history of breast cancer and did not influence serum lipid biomarkers or bone mineral density, although some alterations in bone mineral biomarkers were noted when controlling for menopausal women only.