Studies related to Bone Mineral Density and Red Clover Extract

Red Clover Isoflavones Are Safe And Well Tolerated In Women With A Family History Of Breast Cancer

Effect None
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 401
Gender Female
Age Range 45-64
Body Types Average
Notes for this study:
Supplementation of red clover extract daily over the course of three years was safe and well tolerated in premenopausal and postmenopausal women, but was unable to influence breast density in women with a family history of breast cancer and did not influence serum lipid biomarkers or bone mineral density, although some alterations in bone mineral biomarkers were noted when controlling for menopausal women only.

The Effect Of Isoflavones Extracted From Red Clover (Rimostil) On Lipid And Bone Metabolism

Effect Increase
Trial Design Cohort
Trial Length 1-6 months
Number of Subjects 50
Gender Female
Age Range 45-64
Body Types Overweight
Notes for this study:
Supplementation of Rimostil (from Red Clover) has been noted to improve HDL cholesterol levels by 15.7-28.6% with the dosage range of 28.5-85.5mg, with most efficacy coming from the middle dose of 57mg. There was a significant decrease in apolipoprotein B (11.5-17%) and increase in bone mineral density of 3.1-4%, although the latter was not seen at 28.5mg daily.

While this study was double-blinded, there was not a placebo control used alongside the double-blinded experimental group.

The Effects Of Phytoestrogen Isoflavones On Bone Density In Women: A Double-blind, Randomized, Placebo-controlled Trial

Effect Increase
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 177
Gender Female
Age Range 45-64
Body Types Average
Notes for this study:
Supplementation of 40mg isoflavones from red clover extract daily over the course of a year was able to attenuate the rate of lumbar bone losses () while it had no influence on bone mineral density or bone mineral content of the hip.

The Effects Of Phytoestrogen Isoflavones On Bone Density In Women: A Double-blind, Randomized, Placebo-controlled Trial

Effect None
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 177
Gender Female
Age Range 45-64
Body Types Average
Notes for this study:
Supplementation of 40mg isoflavones from red clover extract daily over the course of a year was able to attenuate the rate of lumbar bone losses () while it had no influence on bone mineral density or bone mineral content of the hip.