| Effect | Decrease |
| Trial Design | Double blind |
| Trial Length | 6+ Months |
| Number of Subjects | 80 |
| Sex | Female |
| Age Range | 45-64 |
| Body Types | Overweight, Average |
Oral supplementation of 398mg red clover extract (120mg isoflavones) for the course of one year failed to improve any vasomotor (hot flash) symptoms of menopause relative to placebo, in a trial where black cohosh was minorly effective and estrogen replacement therapy highly effective.
There was a minor improvement in anxiety symptoms as assessed by the Greene Anxiety scores after 12 months, but not three.
