Effects Of L-Carnitine Supplementation On Serum Inflammatory Factors And Matrix Metalloproteinase Enzymes In Females With Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
|Values||(pg/ml). mean and 25-75th percentile Placebo: before 71.5 (37.0, 184.25), after 93.25 (44.75, 199.75). Carnitine: before 80.0 (35.0, 130.0), after 79.0 (37.5, 126.0)|
|Trial Design||Randomized trial|
|Trial Length||1-6 months|
|Number of Subjects||72|
In a randomized, double-blind, placebo-controlled trial, 72 participants with osteoarthritis took 750 mg of l-carnitine tartrate or placebo for 8 weeks.
There was a statistically significant greater reduction in pain, IL-1-beta, and matrix metalloproteinase-1 but not 13 or c-reactive protein.