Effects Of L-Carnitine Supplementation On Serum Inflammatory Factors And Matrix Metalloproteinase Enzymes In Females With Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
|Values||(pg/ml). mean and 25-75th percentile Placebo: before 459.0 (219.0, 1239.0), after 544 (304.0, 1325.25). Carnitine: before 379.0 (199.0, 707.75), after 296.5 (147.75, 681.5).|
|Trial Design||Randomized trial|
|Trial Length||1-6 months|
|Number of Subjects||72|
In a randomized, double-blind, placebo-controlled trial, 72 participants with osteoarthritis took 750 mg of l-carnitine tartrate or placebo for 8 weeks.
There was a statistically significant greater reduction in pain, IL-1-beta, and matrix metalloproteinase-1 but not 13 or c-reactive protein.