| Effect | Decrease |
| Values | Mean and SD. Placebo: before 0.96 (0.05), after 0.98 (0.06). Carnitine: before, 0.99 (0.18) after 0.95 (0.16). |
| Trial Design | Randomized trial |
| Trial Length | 1-6 months |
| Number of Subjects | 46 |
| Sex | Both Genders |
In a randomized, double-blind trial, 46 participants with diabetes took 3 g of l-carnitine daily for 12 weeks. There was a greater reduction in body weight and BMI, but the difference wasn't statistically significant. There was a greater reduction in waist-hip ratio that was statistically significant compared with baseline, while the change wasn't for placebo. Carnitine performed better for fasting glucose and HbA1c but nonsignificantly.
Triglycerides were reduced statistically significantly more in the carnitine group whereas total cholesterol, Apo-A1, Apo-B (g/L), and HDL, HDL2, and HDL 3 weren't statistically significant. The weight loss for the carnitine group came more from trunk fat than any of the limbs.
