Studies related to HbA1c and L-Carnitine

Comparison Between Orlistat Plus L-carnitine And Orlistat Alone On Inflammation Parameters In Obese Diabetic Patients

Effect Decrease
Values %. Baseline and after 12 months. Other timepoints available in paper. Mean and SD. Control: before 8.4 ± 1.4, after 7.0 ± 0.5. Carnitine: before 8.7 ± 1.6, after 6.5 ± 0.3
Trial Design Randomized trial
Trial Length 6+ Months
Number of Subjects 258
Sex Both Genders
Notes for this study:
In a randomized, double-blind, placebo-controlled trial, 258 participants with uncontrolled type 2 diabetes and obesity took 2 g of l-carnitine daily with or without orlistat for 1 year.

There was a small but statistically significant greater reduction in body weight but not BMI in the carnitine group. HbA1c, fasting glucose, postprandial glucose, and insulin sensitivity were also improved statistically significantly more, while fasting insulin wasn't. LDL and total cholesterol but not HDL or triglycerides were improved significantly more. Adiponectin, but not TNF-a, vaspin, or hs-CRP, was improved significantly more, though the reduction was generally greater for carnitine.

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