Combination Effect Of Pentoxifylline And L-carnitine On Idiopathic Oligoasthenoteratozoospermia
| Effect | Increase |
| Values | Mean and SD. x10⁶. Afterwards only. Placebo 0.8: ± 1.8 Carnitine: 9.3 ± 1.7 Drug: 8 ± 6.5 Combination: 20 ± 4.5 |
| Trial Design | Randomized trial |
| Trial Length | 1-6 months |
| Number of Subjects | 221 |
| Sex | Male |
In a randomized, double-blind, placebo-controlled trial, 221 infertile men with idiopathic oligoasthenoteratozoospermia (IOAT) took either 800 mg of pentoxifylline, 1000 mg of l-carnitine, the combination, or placebo daily for 3 months.
Sperm count, motility, and morphology were the best in the combination group, and there was an apparent benefit of carnitine alone on count and motility but not morphology compared with placebo.
