Studies related to Sex Hormone Binding Globulin and L-Carnitine

Effects Of Carnitine On Thyroid Hormone Action

Effect Decrease
Trial Design Randomized trial
Trial Length 6+ Months
Number of Subjects 50
Sex Female
Notes for this study:
In a randomized, double-blind, controlled trial, 50 participants with hyperthyroidism took 2 or 4 g of carnitine daily for the first 4 months, placebo for the last 2 months, or 2 months of placebo followed by 2 months of carnitine, followed by 2 more months of placebo, while taking T4. There was also a control group that didn't receive carnitine.

In both groups, all symptoms improved statistically significantly besides body weight; these include asthenia, dyspnea, palpitations, nervousness, insomnia, tremors, knee reflexes, and body weight. Asthenia improved significantly more in the group that received 2 months of 4 g of carnitine relative to 2 g, and there were no statistically significant differences in symptoms by dose for the other measures. Total cholesterol and urinary OH-P in the 2-month group and urinary OH-P in the 4-month group. Bone mineral density was improved by carnitine but the difference wasn't statistically significant compared with control.