Effect Of Carnitine-orotate Complex On Glucose Metabolism And Fatty Liver: A Double-blind, Placebo-controlled Study
Notes for this study:
||HOMA-B Mean and SD. Placebo: before 104.8 ± 73.2, after 106.6 ± 51.6. Carnitine: before 122.2 ± 98.1, after 121.4 ± 40.9.
|Number of Subjects
In a randomized, double-blind, placebo-controlled trial, 52 participants with impaired glucose tolerance and fatty liver took 900 mg of l-carnitine in combination with metformin or placebo in combination with metformin daily for 12 weeks.
ALT was the primary outcome, and there was a statistically significantly greater reduction in the carnitine group, but not for AST or ALP. The reduction in hs-CRP and 8-OHdG were also statistically significant, though lipid profile, metabolic markers, blood pressure, and everything else wasn't.