| Effect | Increase |
| Values | (umol/L). Placebo: before 480.5 ± 84.1, after 507.3 ± 121.2. Carnitine: before 550.5 ± 150.1, after 603.2 ± 136.0. |
| Trial Design | Randomized trial |
| Trial Length | 1-6 months |
| Number of Subjects | 60 |
| Sex | Female |
In a randomized, double-blind, placebo-controlled trial, 60 participants with PCOS took 250 mg of carnitine or placebo for 12 weeks.
Mental health was the primary outcome, and there was a statistically significantly greater improvement on the Beck Depression Inventory, Depression Anxiety And Stress Scale, and General Health Questionnaire. There was also a statistically significantly greater increase in total antioxidant capacity, and reduction in malondialdehyde. There was a nonsignificant but notable increase in glutathione.
