| Effect | None |
| Values | Average headache intensity (0–3)a , mean (SD). Baseline: 1.9 (0.4) Placebo: 1.8 (0.4) Carnitine: 1.8 (0.4) |
| Trial Design | Randomized trial |
| Trial Length | 1-6 months |
| Number of Subjects | 72 |
| Sex | Both Genders |
| Age Range | 18-29, 30-44, 45-64 |
In a 12-week randomized, triple-blind, placebo-controlled crossover trial, 72 participants with frequent migraines took placebo or 1.5 g of acetyl-l-carnitine during the first week and 3 g for the rest of the 12 weeks before crossing over.
The primary outcome was days with moderate or severe headaches, and there wasn't a statistically significant difference between treatments for any headache-related measure. The placebo group saw significantly less depression, though the participants weren't particularly depressed.
There wasn't a notable difference in adverse events.
