Studies related to Migraine Severity and L-Carnitine

Acetyl-l-carnitine Versus Placebo For Migraine Prophylaxis: A Randomized, Triple-blind, Crossover Study

Effect None
Values Average headache intensity (0–3)a , mean (SD). Baseline: 1.9 (0.4) Placebo: 1.8 (0.4) Carnitine: 1.8 (0.4)
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 72
Sex Both Genders
Age Range 18-29, 30-44, 45-64
Notes for this study:
In a 12-week randomized, triple-blind, placebo-controlled crossover trial, 72 participants with frequent migraines took placebo or 1.5 g of acetyl-l-carnitine during the first week and 3 g for the rest of the 12 weeks before crossing over.

The primary outcome was days with moderate or severe headaches, and there wasn't a statistically significant difference between treatments for any headache-related measure. The placebo group saw significantly less depression, though the participants weren't particularly depressed.

There wasn't a notable difference in adverse events.

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