Studies related to Serum T4 and L-Carnitine

L-carnitine Supplementation For The Management Of Fatigue In Patients With Hypothyroidism On Levothyroxine Treatment: A Randomized, Double-blind, Placebo-controlled Trial

Effect None
Values (ng/dL) Mean and SD. Placebo: before 1.41 ± 0.19, after 1.42 ± 0.23. Carnitine: before 1.43 ± 0.19, after 1.42 ± 0.20.
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 60
Sex Both Genders
Age Range 18-29, 30-44, 45-64, 65+
Notes for this study:
In 12-week, randomized, double-blind, placebo-controlled trial, 60 participants with primary hypothyroidism who were taking levothyroxine took 1 g of l-carnitine daily or placebo.

The primary outcome was fatigue, and there was a statistically significantly greater reduction in mental fatigue with carnitine, but a nonsignificant reduction with physical fatigue and fatigue severity index. When considered as a percentage who saw improvement, the carnitine group saw statistically significant improvements for all. Younger (less than 50) participants saw greater effects.

There wasn't a statistically significant difference for body composition, fasting glucose, liver enzymes, HbA1c, lipid panel, or thyroid hormones.

There weren't notable differences in adverse events.