Studies related to Lipid Peroxidation and Garlic

Inhibiting Progression Of Coronary Calcification Using Aged Garlic Extract In Patients Receiving Statin Therapy: A Preliminary Study

Effect None
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 23
Gender Both Genders
Age Range 45-64
Body Types Obese, Overweight
Notes for this study:
In a pilot study on persons at high risk for cardiovascular death and already on statin and aspirin therapy, further administration of 1,200mg aged garlic extract (relative to a placebo add-on) for one year reduced the progression in coronary calcium from 22% down to 7.5%. Most other parameters including RBC glutathione concentrations, were unaffected.

Garlic Supplementation Prevents Oxidative DNA Damage In Essential Hypertension

Effect Decrease
Trial Design Cohort
Trial Length 1-6 months
Number of Subjects 40
Gender Both Genders
Age Range 30-44, 45-64
Body Types Overweight, Average
Notes for this study:
8 weeks supplementation with garlic pearls (250mg containing 2.5% garlic oil) in persons with essential hypertension or normal controls (no placebo group) noted a reduction in blood pressure in hypertensives only. The hypertensives were also hypercholesterolemic, but all changes in cholesterol and triglycerides were nonsignificant.

Superoxide and lipid peroxidation in serum were reduced in hypertensives only, and DNA damage was significantly reduced in hypertensives and only trended to be reduced in controls.

Effects Of Garlic Consumption On Plasma And Erythrocyte Antioxidant Parameters In Elderly Subjects

Effect Decrease
Trial Design Cohort
Trial Length 2-4 Weeks
Number of Subjects 13
Gender Both Genders
Age Range 65+
Notes for this study:
Serum lipid peroxidation was reduced by 45% in elderly subjects given garlic supplementation at 100mg/kg bodyweight (raw garlic), which was associated with an increase in the red blood cell activity of glutathione peroxidase (12%) and superoxide dismutase (24%).