Studies related to TNF-Alpha and Garlic

The Effect Of Garlic Tablet On Pro-inflammatory Cytokines In Postmenopausal Osteoporotic Women: A Randomized Controlled Clinical Trial

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 42
Gender Both Genders
Age Range 45-64
Body Types Overweight
Notes for this study:
In postmenopausal and osteoporotic women (45-65 yrs) consuming a 400mg garlic supplement (1.2mcg allicin; equivalent to 2g raw garlic) for one month failed to influence circulating interleukins but reduced TNF-a by approximately 38.7%.

Supplementation With Aged Garlic Extract Improves Both NK And γδ-T Cell Function And Reduces The Severity Of Cold And Flu Symptoms: A Randomized, Double-blind, Placebo-controlled Nutrition Intervention

Effect Increase
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 120
Gender Both Genders
Age Range 18-29, 30-44, 45-64
Body Types Average
Notes for this study:
Supplementation of 2.56g of aged garlic extract to otherwise healthy persons for 90 days was associated with increases in natural killer cells and γδ-T cells in serum (2-fold and 8-fold, respectively), and this was associated with a significantly reduced risk of developing sickness and a lesser decrease in symptoms.

Glutathione in PBMCs was noted to be increased in the garlic group but not control.
Funding issues for this study:
Funded by Kyolic's producers