Studies related to LDL-C and Garlic

Garlic Supplementation And Lipoprotein Oxidation Susceptibility

Effect None
Trial Design Double blind
Trial Length 1-2 Weeks
Number of Subjects 10
Gender Both Genders
Age Range 18-29, 30-44
Notes for this study:
Two weeks supplementation of 600mg garlic powder was able to reduce oxidation of LDL cholesterol, but it appears to be too short a duration of supplementation to affect the lipid panels in these otherwise healthy adults.

Effect Of Garlic On Serum Lipids: An Updated Meta-analysis

Effect Decrease
Trial Design Meta analysis
Trial Length n/a
Number of Subjects 2298
Gender Both Genders
Notes for this study:
A meta-analysis on the influence of garlic supplementation on serum lipids has noted an 8% reduction in total cholesterol, which was said to result in a 38% reduced risk for coronary events (at age 50), there was a lesser increase in HDL-C (1.49mg/dL increase with a 95% CI of 0.19-2.79) and the reduction in LDL reached 6.41mg/dL (95% CI of a 1.05-11.77mg/dL reduction) both of which were significant but this meta-analysis failed to find a significant reduction in triglycerides although it trended towards such (5.45mg/dL reduction ranging from a 14.18 reduction to a 3.27mg/dL increase as the 95% CI)

A Double-blind Crossover Study In Moderately Hypercholesterolemic Men That Compared The Effect Of Aged Garlic Extract And Placebo Administration On Blood Lipids

Effect Decrease
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 41
Gender Male
Age Range 30-44, 45-64
Body Types Overweight
Notes for this study:
7.2g of aged garlic daily for six months in hypercholesterolemic men noted a 7% reduction in total cholesterol and 4.6% reduction in LDL-C alongside a 5.5% reduction in blood pressure.

The Effects Of Time-released Garlic Powder Tablets On Multifunctional Cardiovascular Risk In Patients With Coronary Artery Disease

Effect Decrease
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 51
Gender Both Genders
Age Range 45-64
Body Types Overweight
Notes for this study:
250mg Allicor (garlic powder) twice daily for one year in persons with coronary artery disease was able to significantly reduce total and LDL cholesterol relative to placebo, although the changes in HDL-C and triglycerides were rendered statistically insignificant due to beneficial changes seen in placebo.

The authors concluded a significant reduction in cardiovascular disease risk associated with garlic supplementation relative to placebo.

Inhibiting Progression Of Coronary Calcification Using Aged Garlic Extract In Patients Receiving Statin Therapy: A Preliminary Study

Effect None
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 23
Gender Both Genders
Age Range 45-64
Body Types Obese, Overweight
Notes for this study:
In a pilot study on persons at high risk for cardiovascular death and already on statin and aspirin therapy, further administration of 1,200mg aged garlic extract (relative to a placebo add-on) for one year reduced the progression in coronary calcium from 22% down to 7.5%. Most other parameters including RBC glutathione concentrations, were unaffected.

Lipid-lowering Effects Of Time-released Garlic Powder Tablets In Double-blinded Placebo-controlled Randomized Study

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 42
Gender Both Genders
Age Range 30-44, 45-64
Body Types Overweight
Notes for this study:
Supplementation of 600mg garlic (Allicor) in two divided doses of 300mg daily for 12 weeks in persons with high cholesterol is able to beneficially influence cholesterol and blood pressure without affecting markers of toxicology (immune and red blood cells, liver enzymes) and without any apparent effect on triglycerides.

Protective Effect Of Chronic Garlic Intake On Elastic Properties Of Aorta In The Elderly

Effect None
Trial Design Uncontrolled / observational study
Trial Length 6+ Months
Number of Subjects 101
Gender Both Genders
Age Range 45-64, 65+
Notes for this study:
In older adults who reported consumption of garlic supplements (300-900mg range, average of 460mg) over the previous two years, it was noted that garlic supplement ingestion.

PWV, a measure of aortic stiffness, was lower with garlic and the difference between groups was more notable with older participants; similar trends were noted with EVR (elastic vascular resistance) a measure of blood flow.

Effect Of Garlic And Fish-oil Supplementation On Serum Lipid And Lipoprotein Concentrations In Hypercholesterolemic Men

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 46
Gender Both Genders
Age Range 30-44, 45-64
Body Types Overweight
Notes for this study:
In persons with high cholesterol, 900mg garlic for 12 weeks lowered cholesterol (11.5%), LDL-C (14.2%) with a trend to reduce HDL-C; despite the subjects being normotensive, there was a small reduction in blood pressure seen with garlic (2.4-4.2%).

Aged Garlic Extract Improves Adiponectin Levels In Subjects With Metabolic Syndrome: A Double-blind, Placebo-controlled, Randomized, Crossover Study

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 46
Gender Both Genders
Age Range 30-44, 45-64
Body Types Obese
Notes for this study:
Supplementation of 1,200mg aged garlic extract daily for 12 weeks in obese persons with metabolic syndrome was able to cause a trend (nonsignificant) to reduce weight and was able to significantly increase adiponectin concentrations relative to placebo; all other glucose, cardiovascular, and inflammatory biomarkers measured were unaffected.
Funding issues for this study:
Funded by Wakunaga, producers of the test supplement (Kyolic)

Garlic Supplementation Prevents Oxidative DNA Damage In Essential Hypertension

Effect None
Trial Design Cohort
Trial Length 1-6 months
Number of Subjects 40
Gender Both Genders
Age Range 30-44, 45-64
Body Types Overweight, Average
Notes for this study:
8 weeks supplementation with garlic pearls (250mg containing 2.5% garlic oil) in persons with essential hypertension or normal controls (no placebo group) noted a reduction in blood pressure in hypertensives only. The hypertensives were also hypercholesterolemic, but all changes in cholesterol and triglycerides were nonsignificant.

Superoxide and lipid peroxidation in serum were reduced in hypertensives only, and DNA damage was significantly reduced in hypertensives and only trended to be reduced in controls.

On The Effect Of Garlic On Plasma Lipids And Lipoproteins In Mild Hypercholesterolaemia

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 28
Gender Both Genders
Age Range 30-44, 45-64, 65+
Body Types Overweight
Notes for this study:
300mg of garlic powder thrice daily (900mg total) for 12 weeks in hypercholesterolemic men failed to find any influence of the lipid profiles or the LDL receptor expression on immune cells.

Dietary Supplementation With Aged Garlic Extract Inhibits ADP-induced Platelet Aggregation In Humans

Effect None
Trial Design Cohort
Trial Length 1-6 months
Number of Subjects 23
Gender Both Genders
Age Range 18-29, 30-44
Body Types Average
Notes for this study:
When giving otherwise healthy adults garlic juice (5mL daily for 13 weeks), platelets appeared to have a reduced rate of aggregation in response to ADP (no influence on maximal aggregation level) with a nonsignificant trend to reduce Thromboxane B2. There was actually a trend to reduce triglycerides in these otherwise healthy adults (13%), but that and all other cardiovascular parameters were not significantly influenced except for a reduction in the liver enzyme ALT (20%)

Effects Of Anethum Graveolens And Garlic On Lipid Profile In Hyperlipidemic Patients

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 150
Gender Both Genders
Notes for this study:
In persons with high cholesterol over six weeks, total and LDL cholesterol were found to be reduced with twice daily supplementation of 400mg garlic (1mg allicin) by 12.1% and 17.3% respectively. The 6.3% reduction in triglycerides noted reached significance and HDL increased by 15.7%.

Effects Of Garlic Consumption On Plasma And Erythrocyte Antioxidant Parameters In Elderly Subjects

Effect Decrease
Trial Design Cohort
Trial Length 2-4 Weeks
Number of Subjects 13
Gender Both Genders
Age Range 65+
Notes for this study:
Serum lipid peroxidation was reduced by 45% in elderly subjects given garlic supplementation at 100mg/kg bodyweight (raw garlic), which was associated with an increase in the red blood cell activity of glutathione peroxidase (12%) and superoxide dismutase (24%).