Studies related to Anti-Oxidant Enzyme Profile and Garlic

Inhibiting Progression Of Coronary Calcification Using Aged Garlic Extract In Patients Receiving Statin Therapy: A Preliminary Study

Effect None
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 23
Gender Both Genders
Age Range 45-64
Body Types Obese, Overweight
Notes for this study:
In a pilot study on persons at high risk for cardiovascular death and already on statin and aspirin therapy, further administration of 1,200mg aged garlic extract (relative to a placebo add-on) for one year reduced the progression in coronary calcium from 22% down to 7.5%. Most other parameters including RBC glutathione concentrations, were unaffected.

Supplementation With Aged Garlic Extract Improves Both NK And γδ-T Cell Function And Reduces The Severity Of Cold And Flu Symptoms: A Randomized, Double-blind, Placebo-controlled Nutrition Intervention

Effect Increase
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 120
Gender Both Genders
Age Range 18-29, 30-44, 45-64
Body Types Average
Notes for this study:
Supplementation of 2.56g of aged garlic extract to otherwise healthy persons for 90 days was associated with increases in natural killer cells and γδ-T cells in serum (2-fold and 8-fold, respectively), and this was associated with a significantly reduced risk of developing sickness and a lesser decrease in symptoms.

Glutathione in PBMCs was noted to be increased in the garlic group but not control.
Funding issues for this study:
Funded by Kyolic's producers

Effects Of Garlic Consumption On Plasma And Erythrocyte Antioxidant Parameters In Elderly Subjects

Effect Increase
Trial Design Cohort
Trial Length 2-4 Weeks
Number of Subjects 13
Gender Both Genders
Age Range 65+
Notes for this study:
Serum lipid peroxidation was reduced by 45% in elderly subjects given garlic supplementation at 100mg/kg bodyweight (raw garlic), which was associated with an increase in the red blood cell activity of glutathione peroxidase (12%) and superoxide dismutase (24%).