Studies related to Platelet Aggregation and Garlic

Garlic At Dietary Doses Does Not Impair Platelet Function

Effect None
Trial Design Cohort
Trial Length 1-2 Weeks
Number of Subjects 18
Gender Both Genders
Age Range 18-29, 30-44
Body Types Average
Notes for this study:
Oral ingestion of 4,200mg of raw garlic cloves once, or daily for five days, failed to modify platelet function in otherwise healthy persons.

Dietary Supplementation With Aged Garlic Extract Inhibits ADP-induced Platelet Aggregation In Humans

Effect Decrease
Trial Design Cohort
Trial Length 1-6 months
Number of Subjects 23
Gender Both Genders
Age Range 18-29, 30-44
Body Types Average
Notes for this study:
When giving otherwise healthy adults garlic juice (5mL daily for 13 weeks), platelets appeared to have a reduced rate of aggregation in response to ADP (no influence on maximal aggregation level) with a nonsignificant trend to reduce Thromboxane B2. There was actually a trend to reduce triglycerides in these otherwise healthy adults (13%), but that and all other cardiovascular parameters were not significantly influenced except for a reduction in the liver enzyme ALT (20%)

Aged Garlic Extract, A Modulator Of Cardiovascular Risk Factors: A Dose-finding Study On The Effects Of AGE On Platelet Functions

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 28
Gender Both Genders
Age Range 18-29, 30-44
Body Types Average
Notes for this study:
2,400-7,200mg of aged garlic extract (2,400mg taken for six weeks, which was then doubled for another six weeks and then increased to 7,200mg for the last six weeks) appears to significantly reduce platelet aggregation relative to placebo in otherwise healthy adults.

Changes In Platelet Function And Susceptibility Of Lipoproteins To Oxidation Associated With Administration Of Aged Garlic Extract

Effect Decrease
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 15
Gender Male
Age Range 30-44, 45-64
Body Types Overweight
Notes for this study:
Supplementation of 7,200mg of an aged garlic extract for 3 months (30 men) and continued for another 3 months (15 men) noted that, relative to placebo, there was significantly less platelet aggregation in response to ephedrine, and a small but significant reduction in collagen induced aggregation. There was no influence on ADP, and fibrinogen binding appeared to be reduced 30%.